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冰川冻土 ›› 2002, Vol. 24 ›› Issue (3): 304-307.

• 研究论文 • 上一篇    下一篇

环境微量元素对甘肃河西地区胃癌发病的影响

李玉民1,2, 沈永平3, 薛群基1, 柴琛2, 石斌2, 李汛2, 周文策2, 刘维民1   

  1. 1. 中国科学院, 兰州化学物理研究所, 甘肃, 兰州, 730000;
    2. 兰州医学院, 第一附属医院普外科, 甘肃, 兰州, 730000;
    3. 中国科学院, 寒区旱区环境与工程研究所, 甘肃, 兰州, 730000
  • 收稿日期:2002-01-16 修回日期:2002-05-10 出版日期:2002-06-25 发布日期:2012-04-26
  • 基金资助:
    中国科学院“西部之光”支持项目;中国科学院知识创新工程项目(KZCX1-10-06);国家自然科学基金项目(40172006)

Impact of Environmental Trace Elements on Gastric Cancer in Hexi Region, Gansu Province, China

LI Yu-min1,2, SHEN Yong-ping3, XUE Ji-qun1, CAI Chen2, SHI Bing2, LI Xun2, ZHOU Wen-che2, LIU Wei-min 1   

  1. 1. Lanzhou Institute of Chemical Physics, CAS, Lanzhou Gansu 730000, China;
    2. Clinical Surgery Department of No.1 Hospital of Lanzhou Medicine College, Lanzhou Gansu 730000, China;
    3. Cold and Arid Regions Environmental and Engineering Research Institute, CAS, Lanzhou Gansu 730000, China
  • Received:2002-01-16 Revised:2002-05-10 Online:2002-06-25 Published:2012-04-26

摘要: 环境物质中的微量元素水平与胃癌之间存在相关联系,甘肃省是胃癌高发区,对甘肃省河西地区胃癌患者生活饮用水及土壤微量元素进行了相关性研究.结果表明:河西地区水土的Fe含量高于对照组,高浓度游离Fe有利于癌细胞的快速繁殖,摄入高浓度的离子Fe对机体有毒害作用,是导致胃癌发生的一个重要因素.环境中Zn水平低可能是胃癌发生的癌前因素,Se水平与癌症生病率呈负相关,河西地区环境中镓含量较低,可能导致机体内微量元素的不平衡,促使胃癌的发生.

关键词: 环境微量元素, 胃癌, 河西地区

Abstract: The gastric cancer has been higher in malignant tumor for many years. Factors of gastric cancer have lots of aspects, environment and diet customs are important on progressing of gastric cancer. Hexi area is an area of high disease incidence; the study on trace elements in environment is paid close attention to for exploring diseases cause of gastric cancer. Gastric cancer occurred by more factors together, the changing of some trace elements in environment is relative with gastric cancer. we took the samples in 13 countries of the Hexi region as gastric group, including 70 water samples and 70 soil samples, and took Tianshui city samples as comparison group, then determined 13 kinds trace elements by ICP AES. The result indicate that Fe and Al of water and soil samples are higher in gastric group (P<0.05), the lower are Zn、Ga、Se of soil samples(P<0.05), Ca、Zn、Ga、Sr、Se of water samples(P<0.05). The element changes of water and soil in Hexi area have relationship with gastric cancer(Fe、Al、Zn、Se).Zn and Fe may be the precacerous factor; Cu may be the result after gastric cancer. The values of Cu、Cu/Zn、Fe in serum could offer the foundation for early diagnosis of gastric cancer.

Key words: environmental trace elements, gastric cancer, Hexi region

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  • X18